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Figure 3 In another study, it was found that CD38 was the only significantly upregulated gene or protein after anti-PD-L1 treatment in patients with non-small cell carcinoma (NSCLC)

This suggests that CD38 might be a potential additional immunotherapeutic target in HCC and NSCLC, and can be used together with PD-1/PD-L1 immunotherapy ( Reasons for Choosing CD38 as a Therapeutic Target The main reasons why CD38 has become a tumor treatment target are as follows: (1) In a hypoxic TME, CD38 acts as an extracellular enzyme to catalyze NAD + existing in the TME into ADPR or cADPR