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Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis

Strenuous exercise can increase blood flow to the area and might exacerbate any tenderness or swelling at the injection site

On March 15 and 31, the drainage fluid on the right side tested positive for Ziehl-Neelsen staining (Table 1)

Most of the RCTs included studied only patients with ischemic stroke