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Description

Specifically, activated AhR translocates to the nucleus and binds to specific DNA sequences, leading to the upregulation of genes encoding pro-inflammatory cytokines such as TNF- and IL-6, as well as chemokines like C-X-C motif chemokine ligand (CXCL)8

doi: 10.1098/rstb.2009.0258 158 RwHReB

mRNA levels of various genes was determined using Taqman- or SYBR green-based quantitative PCR (qPCR) technology performed in 7900HT system (Applied Biosystems), and TBP was used as a housekeeping gene