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Last reviewed: June 28, 2026 Last updated: June 28, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Solution should be completely clear and colourless No visible particles, cloudiness, or haziness should be present Liquid should flow freely when pen is tilted Any unusual colour change indicates degradation Discard pens with suspected temperature exposure regardless of appearance Key Takeaways Store unopened Wegovy pens in the refrigerator at 2C to 8C, away from the freezer compartment and not in the door shelves where temperatures fluctuate most Once removed from the fridge, use your Wegovy pen within 28 days maximum, keeping it below 30C and marking the removal date on the pen for easy tracking Never freeze Wegovy under any circumstances, as this irreversibly damages the semaglutide compound and renders the medication ineffective When travelling, carry Wegovy in hand luggage with appropriate cooling equipment, medical documentation, and advance planning for refrigeration at your destination Always inspect your medication before each injection for clarity, colour, particles, and proper consistency, discarding any pen that shows signs of degradation or has exceeded storage limits When to Seek Professional Advice While most storage-related questions can be answered through proper guidance, certain situations require consultation with a healthcare professional or pharmacist

The latter is a common pathway for the degradation of certain amino acids and odd-chain fatty acids

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