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In rodent binge-eating models, lacDrd2KO mice consumed approximately twice the amount of high-fat food as controls, accompanied by enhanced activation of dopaminergic neurons in the mesolimbic reward circuit ( Furthermore, prolactin may interfere with the central leptin signaling pathway ( 4.2 Adipose tissue dysfunction and lipid metabolism Clinical evidence suggests that elevated prolactin levels are strongly associated with disorders of lipid uptake, synthesis, and catabolism ( At the cellular level, prolactin can directly affect adipogenesis by regulating key transcription factor expression

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The same study reported upregulated VEGF and suppressed TGF-beta1, and a shift in the Bcl-2/Bax ratio toward survival the molecular signature the authors used to argue AHK-Cu prolongs the anagen (growth) phase

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