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Acknowledgements The Cryo-EM data were collected at Cryo-Electron Microscopy Research Center, Shanghai Institute of Material Medica

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IGF-1 LR3 Protocol Formats IGF-1 LR3 is only used as an injection

In research protocols, this can be either desirable (for models examining appetite regulation, weight gain, or catabolic disease states) or undesirable (for protocols where appetite stimulation is a confounder)