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In this context, one of the most critical oxidoreductases is hydroxyacid-oxoacid transhydrogenase (HOT) (45), also known in its active form as alcohol dehydrogenase iron-containing protein 1 (ADHFE1)

Acta Obstet Gynecol Scand (2000) 79:1138

The purpose of this review was to elucidate whether insulin/IGF-1 signaling is linked to immunosuppressive STAT3 signaling which is known to promote the aging process