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In relation to the EULAR recommendation, where no consensus was reached on the possibility of using CNS-acting medications in the treatment of comorbidities such as sleep disorders, neurologists agreed on the choice between antidepressants or anticonvulsants on medical judgment when there is a comorbidity for depression or anxiety

Adhere to Ethical and Regulatory Standards: Ensure all research is conducted ethically and complies with relevant institutional and national regulations

Under the acidic (pH 5.06.5.0.5) and high-GSH (210 10 M) conditions of the TME, CREATE undergoes controlled disassembly, leading to the rapid release of the encapsulated BRD4-directed PROTAC molecule, dBET6