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Initially, M1 macrophages secrete pro-inflammatory factors such as interleukin-1, IL-6, and tumor necrosis factor- (TNF-) to eliminate necrotic tissue

Thus, macrophage HIF1 may be a therapeutic target in PNAC and possibly other cholestatic diseases

The transition from animal studies to human populations is often complicated by differences in biological systems, making it difficult to directly translate animal-based results into practical human therapies

Upregulation of GPX4 decreased ferroptosis in MTECs following CaOX treatment To explore the influence of GPX4, a downstream regulator of the ACSL4 pathway, on ferroptosis in oxalate-induced AKI, we overexpressed GPX4 in MTECs