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To avoid this issue, 4-fluorophenylhydrazine was added into the reaction mixture to quantitatively convert pyruvate to 2-(2-(4-fluorophenyl)hydrazono)propanoate ( 23 ) and then used for quantification using 1 H-NMR method (Supplementary Fig

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Zileuton, a 5-LOX inhibitor approved by the FDA and formerly employed in the treatment of asthma, is presently under evaluation for clinical trials in the management of PF [189]

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