interaction of haloacetonitriles with glutathione and glutathione-s-transferase

interaction of haloacetonitriles with glutathione and glutathione-s-transferase General reaction catalyzed by S-transferases Glutathione S-transferase: A versatile and

Name: interaction of haloacetonitriles with glutathione and glutathione-s-transferase General reaction catalyzed by S-transferases Glutathione S-transferase: A versatile and
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Glutathione S transferase: A versatile and dynamic enzyme ScienceDirect PDF) Studies on the mechanism of haloacetonitriles toxicity: Inhibition of rat hepatic glutathione S transferases in vitro Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells Environmental Science & Technology New mechanistic insights into halogen dependent cytotoxic pattern of monohaloacetamide disinfection byproducts ScienceDirect

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10.1093/ilar.52.1.66 ILAR J

In preclinical studies, vitamin C monotherapy at millimolar doses exhibits cytotoxic effects on neuroblastoma, glioma, and GBM cells [80,81,82]

The results showed that after DON treatment, intracellular reactive oxygen species, iron ions, and mitochondrial superoxide significantly increased, while MMP significantly decreased, indicating that DON-induced mitochondrial damage and reduced its activity (Fig