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F., & Nicoletti, V

Chelation therapy can be toxic and has the potential to cause kidney damage, irregular heartbeat, and even death." [4] Cardiovascular disease [edit] Chelation therapy for heart disease began in the 1950s after anecdotal reports that people treated with chelation for heavy metal poisoning had experienced an unexpected relief from symptoms of angina

In addition, in PC12 and N2a cells, low-concentration administration of berberine significantly reduced the amount of ROS generation, lipid peroxidation, and DNA fragmentation, and at the same time increased glutathione content and superoxide dismutase activity (Sadeghnia et al., 2017)