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Int J Clin Med

Two cohorts from the general population (Rotterdam and France) were included in the validation set

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Hpb -GDH was effective at suppressing inflammatory pathways in both mouse and human macrophages and granulocytes by inhibiting the 5-lipooxygenase and instead promoting the cyclooxygenase pathway leading to the synthesis of prostanoids and the downregulation of 5-LOX metabolites ( Nematode-derived cysteine protease inhibitors (cystatins) also have demonstrated anti-inflammatory functions