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Some of the earliest studies on NF-B activation dynamics demonstrated that this activation and negative feedback cycle can lead to periodic oscillations if two criteria are met ( The period and amplitude of NF-B nuclear-cytoplasmic oscillations has been linked to differential gene expression in fibroblasts and epithelial cell lines using single-cell imaging and transcriptome analyses ( NF-B Signaling in Macrophages NF-B signaling in macrophages follows many of the principles elucidated using fibroblasts and other non-hematopoietic cells, with some exceptions