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Therapeutic strategies aiming at iron metabolism as a possible target in MDS and AML can be roughly distributed in four approaches: reduction of iron required for cellular functions via iron chelation, modulation of proteins involved in iron metabolism, induction of ferroptosis und exploitation of iron proteins for the delivery of antileukemic drugs ( Figure 3 )

Improvements in blood cell counts can be seen quickly, while neurological symptoms may take longer to improve, sometimes several weeks or months

To be applied at night time only

Vitamin B12 deficiency, including pernicious anaemia, is commonly encountered in primary care and pharmacists should be able to identify those people most at risk, know the common symptoms and ensure that patients receive adequate and personalised treatment