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doi: 10.1001/archgenpsychiatry.2009.80 72 GuinchatV.ThorsenP.LaurentC.CansC.BodeauN.CohenD

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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

Furthermore, Sirtuin 2(SIRT2) inhibits phosphoenolpyruvate carboxykinase 1 degradation, and Phosphoenolpyruvate carboxykinase, cytosolic [GTP] is the rate-limiting enzyme in gluconeogenesis