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Nevertheless, although a specific action of homocysteine seems to occur at low concentrations, experimental trials have been conducted only with homocysteine administration, which would reflect a severe hyperhomocysteinemia rather than a more physiologic moderate elevation of circulating homocysteine, and clinical observations have only come from homocystinuric patients with severe hyperhomocysteinemia

However, the genes that cause hypermobile EDS (hEDS) the most common form, accounting for about 90% of cases are unknown, so diagnosis is based on a checklist of symptoms

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For example, three-dimensional ultrasound was employed to guide laser application to the lesion site for patients diagnosed with prostate cancer, subsequently utilizing photothermal targeted ablation of the tumor