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For example, higher levels of homocysteine mean that certain proteins important in cardiovascular disease and neurodegenerative diseases can end up with a homocysteine attached or incorporated into them.[ref] The process of post-translational protein modification happens all the time and in a number of different ways, including the addition of other amino acids, sugar molecules, or fatty acids

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The first step is to identify and eliminate the root cause(s) of an illness

Both upregulated and downregulated proteins were computed in accordance with each network to conduct a pathway analysis and identify proteins associated with the pathways of interest ( We additionally used the hypothesis strategy GeneMANIA (freely available at to generate hypotheses regarding gene functions, calculate gene lists, and weight genes, the algorithm of which is designed to automatically weight networks based on the relevance to the gene set