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S -glutathionylation can be caused via thiol-disulfide exchange with GSSG and by activation of thiols to sulfenic acid, sulfenylamides, thiyl radicals, thiosulfinate or S -nitrosyl intermediates (Gallogly and Mieyal, 2007

doi:10.1042/bj2770273

In studies of immune deficiency, centromere instability, and facial anomalies (ICF) syndrome, WGBS revealed a substantial reduction in overall methylation levels, notably in inactive heterochromatin regions, satellite repeats, and transposons (51)