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Inflammatory signaling disrupts insulin action in adipocytes and hepatocytes by impairing key components such as IRS-1, the insulin receptor, and peroxisome proliferator activated receptor gamma (PPAR), thereby exacerbating metabolic dysfunction (53)

Limitations of Preclinical Studies and Translation Barriers The translational potential of current preclinical evidence for human pulmonary hypertension (HPH) faces significant limitations and hurdles

Most flavonoids exhibit poor water solubility, necessitating the use of cosolvents and solvents in experimental settings

Little did I know that I would never leave the lab