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The composition of gut microbiota plays a crucial role in host health, with dietary nutritional characteristics significantly influencing the regulation, maintenance, and proliferation of beneficial microorganisms

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Nonetheless, due to biological and physiological differences between a small animal model and humans, such as a thinner cartilage, possible spontaneous healing of defects, biomechanics, and physical loading in small animals, thus, an additional chondral defect repair study using minipigs should be conducted to confirm these effects