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Archived from the original on 2012-10-06

Additionally, SIN has been reported to prevent the cell cycle from progressing from the G0/G1 phase to the S phase, as well as from G2/M phase, with its immunosuppressive activity on CD4 + primary lymphocytes mainly mediated by cystein-aspartate protease (Caspase-3)-mediated cell apoptosis

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spacer domain generally means any oligo- or polypeptide that functions to link the transmembrane domain to, either the extracellular domain or, the cytoplasmic domain in the polypeptide chain