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It is common for Asian communities to utilize AGIs, especially those who consume diets that are high in complex carbohydrates ( 3.5.1 Mechanism of action In the brush border of enterocytes lining the intestinal villi, -glucoside inhibitors (AGIs) competitively inhibit -glucosidase enzymes, preventing the enzymes from cleaving disaccharides and oligosaccharides into monosaccharides ( 3.5.2 Adverse effects of -glucoside inhibitors The common gastrointestinal side effects caused by AGIs, such as flatulence, stomach pain, and diarrhea, may lead patients to discontinue their medication ( 3.6 Dipeptidyl peptidase-4 inhibitors The DPP-4 inhibitors currently on the market are sitagliptin, vildagliptin, saxagliptin, linagliptin, and alogliptin ( 3.6.1 Mechanism of action DPP-4 inhibitors increase levels of incretin hormones in circulation, notably GLP-1 and GIP