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Critical spatiotemporal gait parameters for individuals with dementia: a systematic review and meta-analysis

Elevated intracellular calcium levels, driven by ATP depletion, triggers chronic dehydration through activation of the KCa3.1 channel (i.e., the Gardos effect), promotes instability of critical cytoskeletal junctional complexes (e.g., spectrin-actin-tropomyosin, spectrin-actomyosin) through post-translational modifications on cytoskeletal adaptor proteins, and leads to activation of proteases (i.e

Results Tubulation repair of the sciatic nerve mitigates misdirection of regenerating tibial motor axons To evaluate the effect of tubulation repair on accuracy of motor nerve regeneration, we employed True Blue (TB) to retrogradely label the tibial motor neuron pool 2 weeks prior to sciatic nerve injury, and labeled the motor neurons which had regenerated their axons into the tibial nerve with a second neuronal tracer FluoroGold (FG) at 3 months after sciatic nerve repair (Fig

In specific embodiments wherein L is a lysosomal protease-sensitive linker, W comprises a cleavable peptide moiety which may be selected from the group consisting of valine- citruline (Val-Cit), alanine-alanine-asparagine (Ala-Ala-Asn), valine-alanine (Val-Ala) and phenylalanine-lysine (Phe-Lys)