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Here is a plain summary of what the evidence supports when you combine Vyvanse and weed: Attention and focus often get worse, not better, because THC impairs the cognitive functions Vyvanse is meant to support Heart rate may increase more than with either substance alone, raising cardiovascular strain Anxiety, irritability, and mood instability can worsen, especially with regular or high-dose THC use Sleep quality tends to suffer even when cannabis seems to help with falling asleep initially Appetite effects conflict directly, with Vyvanse suppressing appetite and THC stimulating it The risk of developing cannabis use disorder rises with frequent use, particularly in people with ADHD That last point comes from a 2025 community-based study of adults with ADHD