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This finding is noteworthy, as specific phosphatidylcholines were previously identified as persistently down-regulated in children who later progressed to islet autoimmunity [37] and clinical T1D [15]

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Over the past few years, viral vector gene therapy has crossed the research and development gap since Luxturna was first approved in 2017, and an increasing number of gene therapies have entered the clinic in the past 4 years, giving scientists confidence that promising nanomaterial-derived gene vectors may benefit patients with retinal diseases more quickly after being more fully studied and tested

The lower K D value determined from competition with His might arise due to the omitting of the formation of a putative ternary complex between HSA, Cu(II) ion and His in the binding scheme, which should result in higher affinity estimates, since the copper in the ternary complex is found in the HMW peak