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However, in the context of chronic bleeding and potential macrophage dysfunction, the release of iron can overwhelm normal storage and handling mechanisms, leading to iron overload [24]

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MaxQuant was set to search with the following parameters: peptide tolerance at 10 ppm, MS/MS tolerance at 0.02 Da, carbamidomethyl (C) as a fixed modification, oxidation (M) as a variable modification, and a maximum of two missed cleavages