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Notably, microglia play a role in synaptic remodeling and contribute to brain development within the nervous system (40, 41)

Among the 36 quinazoline derivatives, compounds 5, 6, 7, 8,9,10, 11, 12, and 13 ( 3745 ) showed potent inhibitory activity against DNMT3A with an IC 50 of 2.4, 1.1, 1.1, 2.7, 1.9, 1.1, 1.0, 2.6, and 1.4 M, respectively (Figure 8)

10.1016/j.mehy.2019.02.014 Med

Indication 3: Treatment of HRS Indication 3: Treatment of HRS Hepatorenal syndrome (HRS) is a serious complication of progressive liver disease involving a complex interplay between circulatory dysfunction, renal physiology, and systemic inflammation