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Hepatic Zip14 deletion alone did not affect systemic Mn levels (Xin et al., 2017), but double KO of both hepatic and intestinal Zip14 did result in significant systemic Mn overload (Hutchens et al., 2023)

Overman MJ, Yothers G, Puhalla SL, Sanoff HK, Cohen DJ, Guthrie KA, Ganz PA, Kopetz S , Lucas PC, Blanke CD, Jacobs SA, Hong TS, Wolmark N, Hochster HS, George TJ, Lima CM