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E.verlandM.RomarheimO

The interaction of these species with specific vascular or interstitial components yield potent chemoattractants for inflammatory phagocytes, establishing a self-amplifying cycle of ROS production that may overwhelm defense strategies resulting in tissue damage (Lewis et al, 1988

Furthermore, reduced insulin signaling in astrocytes leads to an altered astrocyte morphology, reduced mitochondrial function, and altered mitochondrial function [118]