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In the work of Deweirdt et al

The STITCH database includes many potentially important off-targets to particular compounds (derived from experimental data, other curated databases or text mining) in addition to the primary known targets, and all protein-compound interactions in STITCH have an associated confidence metric

In addition to these endogenous sources, exogenous factors such as environmental stresses, accidental leakage of high-dose radiation or ultraviolet light, bacterial infections, and ingestion of harmful chemicals also promote ROS production [4]

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