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Vitamin C is most well-known for its role in the prevention of scurvy, a disease caused by prolonged periods of low dietary vitamin C intake ( 20 million people) are deficient in vitamin C (Schleicher et al., 2009)

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The continual oxidation-reduction cycle, and existence of CoQ 10 in three different redox states, explains its actions as an important cellular redox modulator through its pro-oxidant and antioxidant actions

In an environment with elevated CD38 activity, such as seen in SSc lesional skin, administering NAD + precursors or enhancing NAD + synthesis will have limited effect on increasing NAD + levels, as elevated CD38 continues to degrade NAD +