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The authors concluded that GHK and GHK-Cu increased epidermal cell stemness and keratinocyte proliferation, also increasing p63 and integrin expression [ 48 , 49 ]

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Importantly, plasmid DNA ensures a temporary burst of transgene expression, thus limiting the activity of the CRISPR/Cas9 system and reducing off target toxicity when comparing it to long-term viral vector mediated transgene expression 9

175 Recent advancements include the development of neuroprotective agents 114,176 with potentially profound implications for patient care