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analytical validation principles emphasize method fitness and documented data quality [19] [20]

isoproterenol's short duration of action & bothersome side effects (tremor, tachycardia) reduced its popularity once inhaled formulations of selective beta-2 agonists became available isoproterenol continues to carry an FDA-approved indication for treatment of bronchospasm during anesthesia Subcutaneous SABA Formulations Formulations for subcutaneous injection are useful for treating severe asthma requiring emergency treatment when either aerosolized therapy is not available, or has been ineffective (e.g

FDA Status: Not evaluated or approved by the U

Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen