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doi:10.1186/1749-7221-2-13

The attack of CAR-T on lung epithelial cells expressing low levels of HER2 is considered the main cause of death, resulting in a high level of cytokines in the blood ( Researchers have summarized and introduced in detail strategies to better limit the off-tumor cytotoxicity of CAR-T cells ( in vitro and in vivo studies, it has been confirmed that CAR-T cells expressing this system have significant differences in killing non-tumor cells expressing normal amounts of HER2 and tumor cells expressing 100 fold HER2 ( via intravenous, local intratumoral, and regional intraventricular routes in preclinical settings using human xenograft models of HER2-positive breast cancer with brain metastases

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