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Glutathione is the most prominent antioxidant in the retina and a depletion has been shown to be involved in a number of different types of retinal cell death, as well as stress-induced premature senescence

elegans through increased resistance to environmental stressors

This is consistent with the experiences from clinical trials where treatment times range from 45 s 27 to 90 s 28 , and repetitive short treatment times were favoured 47