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Subcutaneous injection near the injury site is the standard administration method for musculoskeletal indications because proximity to the damaged tissue maximizes the local angiogenic effect

Additionally, in animal models, NNMT gene knockdown has been found to improve insulin sensitivity (IS), glucose tolerance (GT), and overnight fasting glucose (OFG) levels, while also reducing lipid accumulation and triglyceride content (Kraus et al., 2014

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Because it can be stored in the liver for a long period of time, it could be a few years before any sort of symptoms appear