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Treatment of TLS requires vigorous intravenous hydration (Mughal 2014

These include intranasal administration, which allows NGF to bypass the BBB and reach brain parenchyma, and the development of NGF-mimetic small molecules or selective TrkA agonists (Rogdakis et al., 2022

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However, research shows that lean mass loss can be significantly mitigated through resistance training and adequate protein intake during GLP-1 therapy