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However, genetic inactivation of IIS in worms does not mitigate the negative effect of glucose on lifespan 13 (Fig

Consequently, divalent iron converts lipids into reactive oxygen species (ROS), triggering ferroptosis

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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)