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This increased ATP consumption in astrocytes leads to greater glucose uptake, mediated by an increase in glucose transporter production, which in turn boosts glycolysis and lactate production via LDHA

Using an in vitro PHGDH enzyme assay, they determined CBR-5884 to be a weak and selective PHGDH inhibitor (IC 50 = 33 12 mM), whose mode of action involves the disruption of the enzymes tetrameric state in favour of the dimeric conformation 20

Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats

The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework