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Collagen is a widely distributed fibrous protein with a large and complex quaternary structure

The expression level of Ras-related protein 31 (Rab31) is negatively correlated with the sensitivity of cisplatin to stomach adenocarcinoma, and it can activate Twist1 through regulating the Stats/Mucin 1 (MUC-1) signaling, thereby mediating cisplatin resistance and metastasis (59)

Savage MO, Blum WF, Ranke MB, et al

For instance, polysorbate-80-coated polymeric nanoparticles enable efficient delivery of the hexadentate iron chelator desferrioxamine across the BBB, specifically clearing abnormally accumulated iron and Cu ions in the brain