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doi: 10.1016/j.ejcb.2014.07.003 135 MontesinosMCDesaiADelanoDChenJFFinkJSJacobsonMAet al

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Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Because MTX acts as an immunomodulator that suppresses the early expansion of T and B cells, it significantly reduces the body's ability to form these anti-drug antibodies