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Develop, characterize and standardize more relevant animal models of spontaneous, age-related AF

It primarily manifests in the intima of affected arteries as lipid depositions, infiltrations of monocytes and lymphocytes, the migration and proliferation of vascular smooth muscle cells (VSMCs), and the formation of foam cells, lipid striations, and fibrous plaques, which further contributes to vascular wall sclerosis, stenosis, and thrombosis

30 Radiculopathies can not only produce significant weakness, numbness, dysesthesia and radicular pain, but can also cause unilateral or bilateral proximal or distal muscle cramps in the affected myotome

2021;162, Calderon-Dominguez M, Sebastin D, Fucho R, Weber M, Mir JF, Garca-Casarrubios E, et al