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Abstract Lung cancer continues to be a leading cause of cancer-related mortality worldwide, with survival rates stubbornly low despite significant advancements in conventional therapies

In response to the concerns noted above that reduce the sensitivity and specificity of serum B12 and confound the diagnosis of B12 deficiency, many investigators now recommend measuring one functional B12 biomarker (serum methylmalonic acid or serum homocysteine) if serum B12 concentrations appear inadequate to ensure a more accurate assessment of B12 status

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