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AP demonstrates potential therapeutic efficacy in MM management, though its toxicity profile and adverse effects warrant critical consideration, particularly regarding cellular, reproductive, and renal impacts

During the early inflammatory phase of viral infection, viral matrix metalloproteinases and immune-derived cytokines increase bloodbrain barrier permeability, facilitating viral entry and immune cell infiltration into the central nervous system

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In the cAMP/PKA pathway, elevated cAMP levels trigger PKA-mediated phosphorylation of substrates, modulating energy metabolism by promoting glycogen breakdown and fatty acid oxidation to maintain energy balance [31]