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Our statistical analysis highlighted the need to monitor IQOS emissions under different puffing regimes,9 46 47 54 as there are no standard IQOS smoking regimes and the only puffing data collected from users were reported by PMI.41 43 Moreover, PMI used the HCI regime in their studies which could lead to overestimated reductions, as HCI is considered an intense regime for cigarettes.55 Independent research should compare IQOS to other cigarette comparators49 and other available tobacco products before accepting reduced exposure or reduced risk claims.57 84 PMI and independent data agreed that IQOS emits nicotine efficiently,45 55 while reducing exposure to certain HPHCs compared with combustible cigarettes.9 41 However, PMI data showed increases in some emissions from IQOS aerosols compared with cigarette smoke as reported in the comprehensive chemical characterisation.62 Notably, not all these emissions are listed in the FDAs HPHC list (n=93), which was recently criticised for its limited scope ignoring compounds with cardiovascular and pulmonary impact (eg, radicals and particles).113 Moreover, an independent report reviewed the IQOS MRTP application and found that data on 53 of FDAs HPHC list were missing, of which 50 are carcinogens, while 56 other constituents with limited toxicity data (not in the FDA list) were higher in IQOS emissions (eg, up to 13 650% for 2-ethyl-5-methyl-1,4-dioxane) compared with 3R4F.37 The authors noted that this selective reporting of data supports PMIs claim of reduced exposure to HPHCs
Updates will include: To the power: Complete overhaul of engines, including a new Stroker Crank to increase cubic inch to 500
