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406 Mitochondrial dysfunction contributes to cardiac damage, leading to impaired mitophagy, altered enzyme activity in the ETC, and reduced ATP production

In vivo, evidence from animal experiments also supports the role of excess copper in lipid metabolism

If pralidoxime is administered before adequate atropinization , it may temporarily worsen life-threatening muscarinic effects, including: Bronchoconstriction Increased respiratory secretions , which can lead to airway obstruction Therefore, clinical guidelines recommend administering atropine before pralidoxime , and this sequence is reflected in autoinjector design (Aman et al., 2021

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