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In this respect, it is noteworthy that PO primarily predisposes to childhood obesity through complex biological mechanisms (e.g., genetic inheritance, induction of adverse metabolic programming), but also by influencing deleterious lifestyle habits (e.g., children grown by families with obesity frequently have sedentary behaviors and overeating-type eating styles)

Any abnormalities in calcium handling, such as delayed release or reuptake, can impair muscle function and coordination, thereby affecting knee stability and increasing the risk of ACL injury

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