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10.1016/j.ijbiomac.2023.124789 71 LiangY.ChenB.LiangD.QuanX.GuR.MengZ.et al (2023)

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indicates that CD4 + T cells associated with LLV demonstrate elevated expression levels of the Th1 signature transcription factor, TBX21 ( + T cells ( STAT1 transcription factor, which downregulates T-bet, consequently inhibiting the production of IFN- and the activation of CD4 + T cells, thus serving a protective function during HIV infection ( TBX21 gene, which encodes T-bet, as potential risk factors for infection with human genital herpes simplex virus type 2 ( 4.2.2 Bacterial infection T-bet participates in host defense mechanisms against bacterial infections such as tuberculosis, leprosy, and pneumonia by regulating immune cell function and inflammatory responses