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In addition peroxidase induces oxidative stress and changes in the NAD(+)/NADH redox state, leading to the release of cytochrome C from the mitochondria, dysregulation of the expression of Sirtuins and HIF-1, and ultimately retinal pigment epithelial (RPE) cell death

However, after adding Erastin for intervention, we observed that the above protective effects of Cur-NCs were significantly suppressed (Figure 5D)

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The Energy Crisis Theory (Simons & Travell) The most widely accepted explanation comes from Drs